Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes
- 1 August 1983
- journal article
- research article
- Published by Springer Nature in Nature
- Vol. 304 (5927) , 596-602
- https://doi.org/10.1038/304596a0
Abstract
Transfection of embryo fibroblasts by a human ras oncogene does not convert them into tumour cells unless the fibroblasts are established and immortalized before transfection. The embryo fibroblasts become tumorigenic if a second oncogene such as a viral or cellular myc gene or the gene for the polyoma large-T antigen is introduced together with the ras gene.Keywords
This publication has 57 references indexed in Scilit:
- Localization of the adenovirus E1Aa protein, a positive-acting transcriptional factor, in infected cells infected cells.Molecular and Cellular Biology, 1983
- Neoplastic conversion of preneoplastic Syrian hamster cells: rate estimation by fluctuation analysis.Molecular and Cellular Biology, 1983
- The roles of individual polyoma virus early proteins in oncogenic transformationNature, 1982
- Polyoma virus middle T antigen: relationship to cell membranes and apparent lack of ATP-binding activity.Molecular and Cellular Biology, 1982
- The relationship between region E1a and E1b of human adenoviruses in cell transformationGene, 1982
- Multiple arrangements of viral DNA and an activated host oncogene in bursal lymphomasNature, 1982
- Two distinct candidate transforming genes of lymphoid leukosis virus-induced neoplasmsNature, 1981
- Partial transformation of primary rat cells by the leftmost 4.5% fragment of adenovirus 5 DNAVirology, 1980
- Mutation selection and the natural history of cancerNature, 1975
- STEPS IN THE NEOPLASTIC TRANSFORMATION OF HAMSTER EMBRYO CELLS BY POLYOMA VIRUSProceedings of the National Academy of Sciences, 1963