Total cerebral blood flow and metabolism in cerebral vascular disease in relation to hypertension

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Abstract
A series of 22 patients with atherosclerosis and recent infarction or ischemic attack were studied by the iodoantipyrine method of cerebral Wood flow, and determinations of mean arterial pressure, cerebral blood flow, cerebro vascular resistance, cerebral metabolic utilization of glucose and O2, and respiratory quotient were made. The results are compared in a group of 12 without hypertension and 10 with hypertension. Between the 2 groups, only the mean arterial pressure and the cerebral vascular resistance were significantly different. The glucose utilization was depressed in the arterlosclerotic group below that of the hypertensives with a statistical significance at an equivocal level (P = 0.075). Comparison of the overall 22 patients with normal values in a younger group showed highly significant elevation of cerebrovascular resistance and mean arterial pressure and equally significant (P< 0.001) lowering of all other mentioned indexes. In this group of patients, the operative factor in influencing cerebral metabolic function appears to be arteriosclerosis independent of the presence of hypertension.