THE EFFECTS OF SALT RESTRICTION ON THE RENAL CONCENTRATING OPERATION IN NORMAL, HYDROPENIC MAN*
Open Access
- 1 December 1962
- journal article
- research article
- Published by American Society for Clinical Investigation in Journal of Clinical Investigation
- Vol. 41 (12) , 2101-2111
- https://doi.org/10.1172/jci104668
Abstract
Salt restriction in man diminishes the maximal rate of free water reabsorption without changing maximal urine osmolality. Aminophylline corrected the T9H2O defect only when administered at low levels of solute clearance. These findings are best explained by the hypothesis that reduced T9H2O in salt-depleted man results from a reduced medullary salt content secondary to a reduced rate of sodium delivery to the ascending limb at every level of solute clearance.Keywords
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