Genetics of aspirin induced asthma

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Abstract
Although asthma, nasal polyps, and aspirin intolerance are considered as an inherited disease in the catalogue ofMendelian Inheritance in Man,2reports on familial occurrence of AIA are rather scarce. Miller described a pair of sisters with the trait.3 In one of the families described by Lockey et al 4 consanguinity of the parents suggested a recessive inheritance pattern. In the other family a late onset of AIA and discordance between identical twins raised the possibility of an interaction between environmental and genetic factors. Another multiple family with mild asthma sensitive aspirin and dominant inheritance of the trait was described by von Maur et al.5 An early onset of asthma in most affected members of the family and a lack of symptoms of sinusitis or nasal polyposis distinguished this familial variant of AIA.