Genetic and epigenetic alterations as biomarkers for cancer detection, diagnosis and prognosis
Open Access
- 14 March 2007
- journal article
- review article
- Published by Wiley in Molecular Oncology
- Vol. 1 (1) , 26-41
- https://doi.org/10.1016/j.molonc.2007.01.004
Abstract
The development of cancer is driven by the accumulation of scores of alterations affecting the structure and function of the genome. Equally important in this process are genetic alterations and epig...Keywords
This publication has 151 references indexed in Scilit:
- CpG island methylator phenotype underlies sporadic microsatellite instability and is tightly associated with BRAF mutation in colorectal cancerNature Genetics, 2006
- Somatic mutations of epidermal growth factor receptor signaling pathway in lung cancersInternational Journal of Cancer, 2006
- MicroRNA expression profiles classify human cancersNature, 2005
- Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancerNature Genetics, 2005
- Epigenetics in human disease and prospects for epigenetic therapyNature, 2004
- Aberrant CpG-island methylation has non-random and tumour-type–specific patternsNature Genetics, 2000
- The language of covalent histone modificationsNature, 2000
- The Hallmarks of CancerCell, 2000
- Epigenetic lesions at the H19 locus in Wilms' tumour patientsNature Genetics, 1994
- Loss of imprinting of IGF2 is linked to reduced expression and abnormal methylation of H19 in Wilms' tumourNature Genetics, 1994