Prognosis and Relationship of Histologic Features to Clinical Stage

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Abstract
The significance of the wide spectrum of histologic findings observed in Hodgkin's disease has continued to be an enigma, accounting for its unique and somewhat uncertain position in the scheme of malignant neoplasms. Paragranuloma and sarcoma, the histologic types of Jackson and Parker,7are now well established as prognostically significant in a small proportion of cases,1but clinical staging appears to provide a more reliable general basis for prognosis and determination of therapy. Investigation in the past decade has focused attention on a defective immunologic system, as a result of the demonstrated inability todevelop delayed hypersensitivity and delay in homograft rejection.10 The relationship between histologic findings and the clinical stages of Hodgkin's disease reported by this author emphasizes the significance of the histologic features and permits the proposal that the histologic variations are a reflection of differences in the state of the host and possibly related

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