INFLUENCE OF HIGH FAT DIETS ON ALLOXAN DIABETES

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Abstract
High fat diets were given to 20 adult [male] rats of the Long-Evans strain. Eighteen of the animals had severe uncontrolled alloxan diabetes and 2 a transitory diabetes. The amt. of dietary fat was increased progressively at weekly intervals for as long as the rats could tolerate the diet or until a 60% level of fat was reached. Tolerance was detd. by the amt. of ketonuria produced by the diet. While on the high fat diet all of the rats had reduced blood and urine sugar levels and most of the animals gained wit. When 10 of these animals were returned to the basic diet for 3 wks. and the severity of the diabetes was compared with that of the initial basic period, 5 rats showed some improvement in diabetic symptoms. This improvement might have been spontaneous, but more likely it resulted from some recovery of the damaged pancreatic islets which occurred while the animals were on the high fat diets. The wt. gain which occurred during the feeding of high-fat was probably caused by an increased deposition of fat.

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