Prophylactic Intravenous Administration of Standard Immune Globulin as Compared with Core-Lipopolysaccharide Immune Globulin in Patients at High Risk of Postsurgical Infection

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Abstract
Infections and their sequelae are a major cause of death among patients admitted to the surgical intensive care unit (ICU). Studies of passive immunotherapy with standard intravenous immune globulin and hyperimmune globulin directed against gram-negative core lipopolysaccharide to prevent gram-negative infections and their serious systemic complications have had equivocal results in such patients.