METABOLISM OF VANILLIN AND RELATED SUBSTANCES IN THE RAT

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Abstract
Intraperitoneal administration of vanillin (4-hydroxy-3-methoxybenzaldehyde) to rats gave rise to a number of urinary products, chief among which was vanillic acid, in both free and conjugated forms. Other metabolites were conjugated vanillin, conjugated vanillyl alcohol, and catechol (pyrocatechol). Catechol continued to be formed even after treatment of the animals with neomycin and streptomycin for 72 hr. before the vanillin was administered. Besides vanillin, the following exogenous compounds were shown to be sources of urinary catechol protocatechuic aldehyde, protocatechuic acid, vanillic acid, and guaiacol. Nor-adrenalone, adrenalone, and isoprenalone were not precursors. Treatment of rats with disulfiram, an inhibitor of aldehyde oxidase, before the administration of vanillin resulted in a decrease in the proportion of vanillic acid formed and an increase in that of vanillyl alcohol. Disulfiram also interfered with the formation of catechol from guaiacol.

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