Sulla azione di alcuni chinoni naturali sulla attività glucosio — 6 — P Deidrogenasica

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Abstract
INHIBITION OF GLUCOSE-6-P DEYDROGENASE BY OXIDATION PRODUCTS OF NATURAL PHENOLS. — The inhibition of Gl-6-P dehydrogenase activity found in highly concentrated homogenates from potato tuber tissue, seems due to natural occurring orto-di-quinones, such those arising from polyphenoloxidase catalized oxidation of chlorogenic acid, caffeic acid, and tyrosine. These compounds strongly inhibit Gl-6-P dehydrogenase activity of the potato tuber homogenate as well as that of purified Gl-6-P dehydrogenase from yeast. The inhibition effect appears much stronger when the diphenols are oxidized in the presence of the Gl-6-P dehydrogenase. Gl-6-P and TPN efficently protect the enzyme from the inhibition. Ascorbic acid prevents the inhibition by mantaining the diphenols in the reduced form, but is ineffective in reversing the inhibition.