ANTITUMOR-ACTIVITY OF ERBSTATIN, A TYROSINE PROTEIN-KINASE INHIBITOR
- 1 April 1987
- journal article
- research article
- Vol. 78 (4) , 329-332
Abstract
A tyrosine protein kinase inhibitor, erbstatin, showed no antineoplastic effect on L-1210 mouse leukemia when it was injected alone. Erbstatin was found to be inactivated by incubation in serum, but not in dialyzed serum. It was also inactivated in reconstituted serum containing dialyzed serum components and ferric or ferrous ion. Because erbstatin was considered to be inactivated by the ferric or ferrous ion in serum, foroxymithine, which is a potent chelator for the ferric ion, was given to the mice together with erbstatin. Administration of both erbstatin and foroxymithine showed antineoplastic activity against L-1210 leukemia.This publication has 8 references indexed in Scilit:
- Protein phosphorylation at tyrosine is induced by the v-erbB gene product in vivo and in vitroCell, 1985
- The neu oncogene: an erb-B-related gene encoding a 185,000-Mr tumour antigenNature, 1984
- Close similarity of epidermal growth factor receptor and v-erb-B oncogene protein sequencesNature, 1984
- Nucleotide sequence of the feline retroviral oncogene v-fms shows unexpected homology with oncogenes encoding tyrosine-specific protein kinases.Proceedings of the National Academy of Sciences, 1984
- Simian Sarcoma Virus onc Gene, v- sis , Is Derived from the Gene (or Genes) Encoding a Platelet-Derived Growth FactorScience, 1983
- Avian sarcoma virus UR2 encodes a transforming protein which is associated with a unique protein kinase activityJournal of Virology, 1982
- Structural and functional domains of the Rous sarcoma virus transforming protein (pp60src).Proceedings of the National Academy of Sciences, 1981
- Characterization of Y73, an avian sarcoma virus: a unique transforming gene and its product, a phosphopolyprotein with protein kinase activity.Proceedings of the National Academy of Sciences, 1980