Induction of immune responsiveness in a genetically low‐responsive tumor‐host combination by chemical modification of the immunogen

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Abstract
Trinitrophenylated Moloney virus‐induced YAC cells induced a higher cytotoxic antibody response and better protection against small tumor cell doses in syngeneic, low‐responsive strain A mice than nonmodified YAC cells that had been inactivated by irradiation or mitomycin C treatment. The results indicated that genetically determined low responsiveness to a virally induced antigen can be overcome, at least to some extent, by coupling the immunizing cells to a strong immunogenic hapten.