Synthesis of 24ξ,25-dihydroxyprovitamin D3
- 1 January 1976
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- No. 7,p. 727-731
- https://doi.org/10.1039/p19760000727
Abstract
The known C-22 aldehyde obtained by degradation of ergosterol acetate (in which the ring B diene system has been protected by Diels–Alder addition of 4-phenyl-1,2,4-triazoline-3,5-dione) undergoes aldol condensation with 3-methyl-3-tetrahydropyranyloxybutan-2-one. The resulting enone gives 24ξ,25-dihydroxyprovitamin D3(the provitamin of the metabolite 24,25-dihydroxycholecalciferol) upon successive reductions with sodium borohydride in pyridine and lithium aluminium hydride.This publication has 0 references indexed in Scilit: