Further Observations on the Effects of Autonomic Blocking Agents in Patients with Hypertension

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Abstract
Hexamethonium and pentamethonium produced a greater reduction in blood pressure in patients with malignant hypertension who had low serum concentration of sodium or severe encephalopathy than in those with benign hypertension. Concurrent administration of hydrazinophthalazine resulted in an additive effect on the blood pressure of most patients, with slower development of tolerance and less marked postural hypotension. In many patients there was improvement in signs and symptoms attributable to hypertension. Harmful effects of reduction in blood pressure occurred mainly in patients with malignant hypertension and consisted of renal insufficiency and evidence of myocardial and retinal ischemia.