Interference by acetaminophen in the glucose oxidase-peroxidase method for blood glucose determination.
Open Access
- 1 October 1976
- journal article
- research article
- Published by Oxford University Press (OUP) in Clinical Chemistry
- Vol. 22 (10) , 1729-1731
- https://doi.org/10.1093/clinchem/22.10.1729
Abstract
Acetaminophen, p-aminophenol, and oxyphenbutazone interfere with the glucose oxidase/peroxidase method for glucose. Structurally related compounds that lack a free phenolic hydroxyl group (acetanilide, aniline, and phenylbutazone) do not interfere. During the analytical procedure acetaminophen is consumed. One mole of acetaminophen leads to an apparent loss of four moles of glucose. The hexokinase/glucose-6-phosphate dehydrogenase method (Boehringer Hexokinase method) is not affected by these substances.This publication has 1 reference indexed in Scilit:
- Evaluation of the hexokinase/glucose-6-phosphate dehydrogenase method of determination of glucose in urineAnalytical Biochemistry, 1968