Structure elucidation and absolute configuration of the tyledosides, bufadienolide glycosides from Tylecodon grandiflorus
- 1 January 1986
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- No. 3,p. 429-435
- https://doi.org/10.1039/p19860000429
Abstract
The isolation and characterization of six related bufadienolide glycosides, tyledosides A, B, C, D, F, and G from Tylecodon grandiflorus(Burm. F) Toelken are reported. The structure elucidation of these metabolites is based on a detailed study of their highfield 1H and 13C n.m.r. spectra. Extensive use was made of two-dimensional homonuclear and heteronuclear correlation experiments in the assignment of the n.m.r. spectra. The results obtained upon chemical derivatization of tyledosides A, C, and D are in agreement with the assigned structures.Keywords
This publication has 5 references indexed in Scilit:
- The structure of cotyledoside, a novel toxic bufadienolide glycoside from Tylecodon wallichii(Harv.) ToelkenJournal of the Chemical Society, Perkin Transactions 1, 1984
- Cardenolide glycosides of the asclepiadaceae. New glycosides from asclepias fruticosa and the stereochemistry of uscharin, voruscharin and calotoxinJournal of the Chemical Society, Perkin Transactions 1, 1983
- 7β,8β-Epoxycardenolide glycosides of Asclepias eriocarpaJournal of the Chemical Society, Perkin Transactions 1, 1980
- Stereochemistry of the hexosulose in cardenolide glycosides of the asclepiadaceaeJournal of the Chemical Society, Perkin Transactions 1, 1980
- 1α,2α-epoxyscillirosidine, the main toxic principle of Homeria glauca (Wood and Evans) N.E. Br.Tetrahedron, 1966