Inhibition of IgG complex-induced platelet aggregation by antiglobulin-active cryoglobulin IgM components.

  • 1 November 1973
    • journal article
    • Vol. 15  (3) , 393-408
Abstract
Aggregation of human platelets (P1.A) induced by IgG immune complexes of rabbit (Ea–aEa, NIP2–24 BSA–aNIP) and human (tetanus toxoid-aT) origin and by heat-aggregated human polyclonal IgG was inhibitable by antiglobulin-active IgM components dissociated from IgM-IgG cryoglobulins. The inhibitory capacity of the Cryo-IgM components extended over a wide range of Ag:Ab ratios on both sides of the equivalence, and likewise over a wide range of epitope densities on the Ag portion of the P1.A active Ag–Ab complex. In contrast to the inhibitability of IgG complex-induced P1.A was the total lack of inhibition by Cryo-IgM components of P1.A induced by anti-platelet rabbit antibodies.