On the origins of arrestin and rhodopsin
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Open Access
- 1 January 2008
- journal article
- research article
- Published by Springer Nature in BMC Ecology and Evolution
- Vol. 8 (1) , 222
- https://doi.org/10.1186/1471-2148-8-222
Abstract
G protein coupled receptors (GPCRs) are the most numerous proteins in mammalian genomes, and the most common targets of clinical drugs. However, their evolution remains enigmatic. GPCRs are intimately associated with trimeric G proteins, G protein receptor kinases, and arrestins. We conducted phylogenetic studies to reconstruct the history of arrestins. Those findings, in turn, led us to investigate the origin of the photosensory GPCR rhodopsin.Keywords
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