The origin of the adnexal tumors of the skin: a viewpoint

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Abstract
Histogenesis of adnexal tumors of the skin has not been the subject of an independent study or a publication since the theory of pluripotentiality of epithelial matrix cells was introduced and applied to the origin of adnexal tumors some 25 years ago. In this period, a number of new tumor entities have been described. Histologic studies as well as enzyme histochemistry, electron microscopy and, lately, the results of the application of monoclonal antibodies have provided a wealth of new information. In this article a review of the histogenesis of adnexal tumors is made and, based on clinical and histologic data provided, an alternative view for origin of adnexal tumors of the skin is proposed.