A NEW METHOD FOR NONINVASIVE QUANTITATION OF SEGMENTAL MYOCARDIAL WALL THICKENING USING TC-99M 2-METHOXY-ISOBUTYL-ISONITRILE SCINTIGRAPHY - RESULTS IN NORMAL SUBJECTS

  • 1 February 1990
    • journal article
    • research article
    • Vol. 31  (2) , 173-177
Abstract
A quantitative index of regional myocardial wall motion obtained from electrocardiogram-gated perfusion images has been assessed. The assumption for the propsosed algorithm is that, according to the partial volume effect, the recovery counts by the instrumentation is a function of the object size. Systo-diastolic changes in the detected radioactivity would therefore reflect changes in myocardial wall thickness. Ten normal volunteers were studied in control conditions by 99mTc 2-methoxy-isobutyl-isonitrile scintigraphy. Electrocardiogram (ECG)-gated images were acquired in multiple projections. End-diastolic and end-systolic activity was measured along radii from the center to the edge of the left ventricle. Data are displayed as circumferential profiles and the percent systolic thickening determined according to the formula (end-systolic profile end-diastolic profile) (end-diastolic profile + background .times. 100). The intra- and interobserver variabilities were .+-. 5.4% and .+-. 4.1%, respectively. Analysis of regional systolic thickening showed a heterogeneous pattern, with a maximum and minimum value of 35% and 27% located to infero-apical and to the proximal anterior wall, respectively. Our values correlate well with those reported for normals using cine computed tomography or nuclear magnetic resonance.

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