Cyclophosphamide Inhibition of Experimental Allergic Encephalomyelitis in Wistar Rats.

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Abstract
Cyclophosphamide at dose levels of 12 through 5 mg/k given intraperitoneally daily or 5 days/week from time of nervous tissue-adjuvant sensitization through the 17th post-sensitiza-tion day inhibits experimental allergic encephalomyelitis (EAE) in albino rats. The EAE-inhibitory effect persists for at least 3 weeks after stopping cyclophosphamide. Inhibition of EAE is associated with suppression of complement-fixing antibodies and variable depression of circulating peripheral blood leukocytes. Evidence is presented that the EAE -inhibitory action of this alkylating agent has an immunological basis rather than an anti-inflammatory one.