Facile Synthesis of Cyclic Tetrapeptides from Nonactivated Peptide Esters on Metal Centers

Abstract
The cyclization of dipeptide esters of α-, β-, γ-, and δ-amino acids can be achieved by using NiII, PdII, or CuII templates. The structure of one of the complexes (1) obtained, which was determined by X-ray crystallography, reveals that the anions form layers and are linked to water molecules by hydrogen bonds.

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