Structural effects in drug distribution: whole animal pharmacokinetics

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Abstract
Computer-generated data simulating the results of assays of homogenized whole animals as a function of time following rapid intravenous injection have been employed to calculate various pharmacokinetic constants in both one and two compartment open models. The results have been compared to those obtained with data representing analysis of blood samples at identical time intervals. Data for whole animal analysis are equally reliable in calculating the first-order constants for distribution and elimination when applied to the appropriate cases. However, the range of utility is smaller when the whole animal method is used. The whole animal approach does offer some unique advantages over the classical plasma data method and these are discussed. The range of utility and the method for calculating pharmacokinetic rate constants from whole animal data are clearly defined.

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