Effects of penicillamine on distribution of B6 vitamers in rat urine.
- 1 January 1978
- journal article
- research article
- Published by Center for Academic Publications Japan in Journal of Nutritional Science and Vitaminology
- Vol. 24 (1) , 1-7
- https://doi.org/10.3177/jnsv.24.1
Abstract
The antivitamin B6 effect of DL- and D-penicillamine was studied in rats. A considerable elevation in the urinary excretion of vitamin B6 activity (pyridoxal and its thiazolidine derivative) was a parameter of B6 antagonism. Both DL- and D-penicillamine had an antivitamin B6 effect in rats, although that induced by the DL-form is considerably greater, as would be expected from previous studies. B6 supplementation should be included in any long-term penicillamine therapy, regardless of the isomer that is employed.This publication has 7 references indexed in Scilit:
- The effect of castrix (2-chloro-4-dimethylamino-6-methylpyrimidine) on the distribution of B6 vitamers in mouse brainBiochemical Pharmacology, 1976
- Effects of PENICILLAMINE on the contents of B6 vitamers of the mouse brain.Journal of Nutritional Science and Vitaminology, 1976
- The Antipyridoxine Effect of Penicillamine in Man*Journal of Clinical Investigation, 1964
- An increased vitamin B6 requirement in the rat on a diet containing l-penicillamineArchives of Biochemistry and Biophysics, 1957
- Some factors affecting the inhibitory action of thiamine on the growth of Saccharomyces carlsbergensisArchives of Biochemistry and Biophysics, 1956
- INHIBITION OF THE GROWTH OF THE RAT BY l-PENICILLAMINE AND ITS PREVENTION BY AMINOETHANOL AND RELATED COMPOUNDSJournal of Biological Chemistry, 1950
- The Chemistry of Vitamin B6. VI. Pyridoxylamino Acids1Journal of the American Chemical Society, 1948