From sequences to a functional unit
- 13 March 2006
- journal article
- research article
- Published by American Physiological Society in Physiological Genomics
- Vol. 25 (1) , 1-8
- https://doi.org/10.1152/physiolgenomics.00166.2005
Abstract
Functional insights at the gene product level would help the drug discovery industry to effectively tap targets for therapeutics and biomedical applications. A complete functional unit can be multidomain, and it is the co-occurrence and interaction of these multiple domains that determine the function and functional diversity of their gene products. With at least 10% of genes from complete genomes existing in fused form, identifying gene fusion events helps us categorize the protein universe into distinct functional units with only sequence information.Keywords
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