Distribution and Turnover of Administered Rubidium (Rb86) Carbonate in Blood and Urine of Man

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Abstract
Intraven. admd. Rb86 was rapidly cleared from the blood. Within 48 hrs. approx. 10% of the dose was concd, in the total red-cell mass. This level was maintained for 12 days. The plasma retained 0.5_0.6% of the injd. Rb86, and the red cell:plasma ratio of Rb content was 20:1. Rb86 was readily incorporated into red cells in vitro. Prolonged dialysis removed less than 15% of the isotope from the erythrocytes; however, 94% was removed when the cells were first hemolyzed. When an hemolysate of red cells was treated with protein precipitants, the Rb86 largely remained in the supernatant fluid. Advantageous characteristics of this isotope for red cell volume detns. are noted. Urinary excretion of Rb by the human is slow, only 14% of an admd. dose being accounted for by this route during 12 days of observation. This is similar to the rate reported for the cat and dog but far less than that for the guinea pig and rabbit. The reason for this difference is not known.

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