Extracellular 5-hydroxytryptamine concentration in rat hypothalamus after administration of fluoxetine plus l-5-hydroxytryptophan

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Abstract
Fluoxetine (10 mg kg−1, i.p.) caused a three- to fourfold increase in extracellular 5-hydroxytryptamine (5-HT) concentration measured by microdialysis in hypothalamus of freely moving rats. The addition of l-5-hydroxytryptophan at 20 or 40 mg kg−1, i.p. doses, magnified the increase in extracellular 5-HT to as much as 16 times basal levels, although these doses of l-5-hydroxytryptophan alone had only small effects on extracellular 5-HT. The increased formation of 5-HT following l-5-hydroxytryptophan administration appears to overcome homeostatic mechanisms that limit the increases in extracellular 5-HT caused by uptake inhibition.