Subcellular Distribution of Ascorbic Acid in Rat Brain.
Open Access
- 1 January 1978
- journal article
- research article
- Published by Elsevier in The Japanese Journal of Pharmacology
- Vol. 28 (5) , 789-791
- https://doi.org/10.1254/jjp.28.789
Abstract
A low concentration of L-ascorbic acid (5 .times. 10-6 M) induced a Ca2+-dependent (10-6-10-5 M) acetylcholine [ACh] release from isolated synaptic vesicles in the presence of ATP and Mg2+. Ascorbic acid apparently may be associated with the function of the nervous system, particularly with dynamic states of transmitters in the nerve terminals. Under physiological conditions, concentration of ascorbic acid in the brain was over 2 mM, such levels being sufficient for ACh release. Accordingly the ACh release from the vesicles is considered to be physiologically regulated by Ca2+.This publication has 12 references indexed in Scilit:
- Effects of Synaptic Plasma Membranes on Release of Acetylcholine from Synaptic VesiclesThe Japanese Journal of Pharmacology, 1978
- On the brain ascorbic acid and its importance in metabolism of biogenic aminesLife Sciences, 1977
- FACTORS REQUIRED FOR Ca‐SENSITIVE ACETYLCHOLINE RELEASE FROM CRUDE SYNAPTIC VESICLESJournal of Neurochemistry, 1976
- Specificity of ascorbic acid transport system of the central nervous systemAmerican Journal of Physiology-Legacy Content, 1974
- Transmitter release induced by injection of calcium ions into nerve terminalsProceedings of the Royal Society of London. B. Biological Sciences, 1973
- Vitamin C as a requirement for the storage of norepinephrine by the irisBiochemical Pharmacology, 1969
- A Deficient Binding Mechanism for Norepinephrine in Hearts of Scorbutic Guinea PigsExperimental Biology and Medicine, 1966
- The separation of synaptic vesicles from nerve-ending particles (‘synaptosomes’)Biochemical Journal, 1964
- THE VITAMIN C CONTENT OF HUMAN TISSUESJournal of Biological Chemistry, 1934