Induction of Immunological Tolerance by Oral Administration of Nickel and Chromium
- 1 February 1984
- journal article
- research article
- Published by SAGE Publications in Journal of Dental Research
- Vol. 63 (2) , 124-128
- https://doi.org/10.1177/00220345840630020501
Abstract
Oral administration of nickel-chromium to guinea pigs by way of a fixed occlusal splint, or the incorporation of metallic powder or salts into the pelleted food, did not induce hypersensitivity to these metals. In addition, a subsequent attempt to immunize the pre-treated guinea pigs failed in most animals, whereas non-pre-treated guinea pigs became clearly hypersensitive. These results show that oral administration of nickel and chromium induced a state of (partial) tolerance to both metals.This publication has 22 references indexed in Scilit:
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