CONCENTRATION GRADIENTS FOR RADIOIODIDE IN UNBLOCKED THYROID GLANDS OF RATS: EFFECTOF PERCHLORATE1

Publisher Website
Google Scholar
Abstract
THE iodide-trapping mechanism of the thyroid provides a concentrated substrate for subsequent organic iodinations within the gland. Obliteration of this function, by anions such as thiocyanate or perchlorate, results in diminished formation of hormone, goiter, and myxedema (Barker, 1936; Astwood, 1943; Rawson, Tannheimer and Peacock, 1944; Wolff et al., 1946; VanderLaan and VanderLaan, 1947; Wyngaarden, Wright, and Ways, 1952). Under conditions of blockade to organic binding, external counting techniques in man have repeatedly demonstrated within the gland concentrated radioiodide which can readily be discharged by thiocyanate or perchlorate (Stanley and Astwood, 1948; Stanbury and Wyngaarden, 1952). Similar attempts to demonstrate dischargeable thyroidal radioiodine have met with variable succees when organic-binding has been allowed to proceed (Kirkland, 1954; Berson and Yalow, 1955; Ingbar, 1955; VanderLaan, 1955). Several investigators, having been unable consistently to demonstrate dischargeable radioiodine under the latter conditions, have concluded that organic-binding of concentrated iodide is virtually instantaneous (Berson and Yalow, 1955; VanderLaan, 1955).