Removal of small and large molecules from microinjection sites in rat skeletal muscle

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Abstract
The rates at which colloidal molecules (T 1824-labeled albumin) and diffusible molecules (water blue) are removed from microinjection sites have been studied in the spinotrapezius muscle of rats. Under control conditions the small molecule is removed about 60 times more rapidly than the larger molecule. When the blood perfusing the muscle is diluted by close arterial infusion of saline the rate of removal of both large and small molecules is increased. Similar infusion of a hyperoncotic solution increases the rate of the diffusible molecule but decreases the rate of removal of colloid. These findings, which are qualitatively the same as those obtained from similar experiments on the mesentery of the rat, suggest that augmented filtration from the vascular bed increases rate of removal of colloid and hence that this is a reasonable method for estimating the rate of local lymph flow.

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