BEHCETS SYNDROME - IMMUNOPATHOLOGIC AND HISTOPATHOLOGIC ASSESSMENT OF PATHERGY LESIONS IS USEFUL IN DIAGNOSIS AND FOLLOW-UP

  • 1 January 1985
    • journal article
    • research article
    • Vol. 109  (8) , 747-751
Abstract
Behcet''s syndrome is a complex multisystem disease that, due to the absence of a pathognomonic laboratory test, must be diagnosed using clinical criteria. Clinical pathergy testing, the induction of a sterile pustule 24 h after cutaneous trauma, was proposed as a useful adjunct to diagnosis. This concept was expanded by showing the usefulness of examining pathergy lesions by routine and immunofluorescence microscopy in the diagnosis of 9 patients with Behcet''s syndrome. Histopathologic pathergy assessments correlated with clinical disease activity and/or response to experimental oral thalidomide therapy in 5 of 6 patients with Behcet''s syndrome who were retested.

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