PRE-CLINICAL TOXICOLOGIC EVALUATION OF ICRF-187 IN DOGS

  • 1 January 1980
    • journal article
    • research article
    • Vol. 64  (12) , 1211-1215
Abstract
Single- and multiple-treatment schedules in dogs were used to evaluate the toxicity of [the antineoplastic drug] ICRF-187. The major target organs were the bone marrow, lymphoid tissue, gastrointestinal tract, liver and kidney. Liver, kidney and intestinal toxic effects were most severe at lethal doses. Toxic effects on the kidney and intestinal tract were reduced or absent at lower doses. Hepatotoxicity was most severe after single doses and was only slowly reversible at high doses. Repeated dosage regimens had the greatest effect on circulating blood cells; anemia and neutropenia were most prominent after 3 series of 5 daily doses with rest periods between series. ICRF-187 was more toxic to dogs in terms of total dose received when administered in 5 daily doses than in single doses. A rest period between series of 5 daily doses allowed a larger total dose to be administered.