Glycodelins: role in regulation of reproduction, potential for contraceptive development and diagnosis of male infertility
Open Access
- 1 June 1998
- journal article
- review article
- Published by Oxford University Press (OUP) in Human Reproduction
- Vol. 13 (suppl 3) , 262-269
- https://doi.org/10.1093/humrep/13.suppl_3.262
Abstract
Glycodelins are glycoproteins synthesized in various glands, with sequence homology to β-lactoglobulins, and named according to their unique oligosaccharide structures. We purified, cloned and sequenced endometrium- and seminal plasma-derived glycodelins (GdA and GdS respectively) and found that they are involved in various types of cell–cell communications. These include interactions between the spermatozoon and the egg, and between immune cells and their targets. Endometrial GdA inhibits sperm–egg binding, whereas the differently glycosylated GdS in seminal plasma does not. These observations are of interest for reproductive physiology, detection of causes of infertility, and they also may have potential for contraceptive development.Keywords
This publication has 0 references indexed in Scilit: