Histone macroH2A1.2 is concentrated in the XY compartment of mammalian male meiotic nuclei
- 26 June 2000
- journal article
- Published by S. Karger AG in Cytogenetic and Genome Research
- Vol. 89 (1-2) , 118-120
- https://doi.org/10.1159/000015589
Abstract
We show here that histone macroH2A1.2 concentrates at the transcriptionally silent XY body, normally being formed during male meiosis in the mouse. A similar accumulation has earlier been observed on the inactive X chromosomes of somatic adult female mammalian cells by Costanzi and Pehrson (1998). This correspondence in the nature of heterochromatinization of the X chromosomes in males and females adds another property of X chromosome inactivation that is shared by males and females at different phases of their life cycle.Keywords
This publication has 5 references indexed in Scilit:
- Conditional deletion of Xist disrupts histone macroH2A localization but not maintenance of X inactivationNature Genetics, 1999
- Histone macroH2A1 is concentrated in the inactive X chromosome of female mammalsNature, 1998
- XIST RNA paints the inactive X chromosome at interphase: evidence for a novel RNA involved in nuclear/chromosome structure.The Journal of cell biology, 1996
- The inactive X chromosome in female mammals is distinguished by a lack of histone H4 acetylation, a cytogenetic marker for gene expressionCell, 1993
- X inactivation in mammalian testis is correlated with inactive X–specific transcriptionNature Genetics, 1992