Spread of a Single Plasmid Clone to an Untreated Individual from a Person Receiving Prolonged Tetracycline Therapy
Open Access
- 1 August 1977
- journal article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 12 (2) , 219-225
- https://doi.org/10.1128/aac.12.2.219
Abstract
The aerobic gram-negative intestinal flora of two individuals living in close proximity was followed for 17 months. One of these persons was receiving a prolonged tetracycline treatment for acne vulgaris and was colonized by tetracycline-resistant Escherichia coli strains throughout the survey. The other person studied received no antibiotics during the period in question, but was frequently found to excrete a number of E. coli strains harboring tetracycline-resistant plasmids. The two E. coli strains (O75.H7 and O23.H16) excreted from both persons most frequently were indistinguishable, and so were the R-plasmids they carried. This suggests that R-plasmid-carrying E. coli may spread from individuals under treatment to close relatives that have not been treated.Keywords
This publication has 13 references indexed in Scilit:
- R-Plasmid Transfer In Vivo in the Absence of Antibiotic Selection PressureAntimicrobial Agents and Chemotherapy, 1976
- Phage lambda receptor chromosomes for DNA fragments made with restriction endonuclease III of Haemophilus influenzae and restriction endonuclease I of Escherichia coliJournal of Molecular Biology, 1975
- Antibiotic resistance and survival of E coli in the alimentary tractBMJ, 1975
- Distribution of R Plasmids Among the O-Antigen Types of Escherichia coli Isolated from Human and Animal SourcesAntimicrobial Agents and Chemotherapy, 1975
- A simple method for the preparation of large quantities of pure plasmid DNABiochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1975
- Studies on the cleavage of bacteriophage lambda DNA with EcoRI restriction endonucleaseJournal of Molecular Biology, 1975
- R FACTORS IN ESCHERICHIA COLI IN FÆCES AFTER ORAL CHEMOTHERAPY IN GENERAL PRACTICEThe Lancet, 1971
- [Stability of coli flora of the healthy human. 1. The occurrence of permanent and changing types].1969
- Mutant Drug Resistant Factors of High TransmissibilityNature, 1967
- Purification and properties of bacteriophage MS2 and of its ribonucleic acidJournal of Molecular Biology, 1963