Comparison of Permeability in High-Grade and Low-Grade Brain Tumors Using Dynamic Susceptibility Contrast MR Imaging

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Abstract
OBJECTIVE. The purpose of this study was to compare permeability measurements in high-grade and low-grade glial neoplasms using a T2*-weighted method. Our hypothesis was that permeability measurements using a T2*-weighted technique would show permeability in high-grade neoplasms to be higher than that in low-grade neoplasms.MATERIALS AND METHODS. Twelve patients with biopsy-proven high-grade neoplasms and 10 patients with biopsy-proven low-grade neoplasms underwent dynamic susceptibility contrast MR perfusion imaging (TR/TE, 1500/80) after bolus infusion of 0.2 mmol/kg of MR contrast material. Color-coded permeability-weighted maps were created using a model that weights relative contributions to signal intensity from intravascular T2* effects and extravascular T1 effects from blood-brain barrier permeability. Two measures of permeability were performed: mean value of highest permeability found on three images through the tumor (mean regional value) and highest value found at any region of interest in the...