Indirect Determination of Bromhexine by Atomic Absorption Spectrophotometry

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Abstract
A new procedure for determination of Bromohexine is described. The method consists of extracting an ion pair between the Bromhexine and the inorganic complex Co(SCN)2 4 and measuring Co in the organic phase by AAS at 240. 7 nm. The optimal experimental conditions: pH, concentration of Co(SCN)2 4, shaking time, phase ratio, number of extractions and the linear range of calibration are studied. The organic phase used is 1,2-dichloroethane. The standard deviation of the method is 10−3. The interference of foreign substances which accompany the Bromhexine in pharmaceutical preparations is studied, and the method is applied to their quantitative determination in medicines.