Regulation and biosynthesis of secondary metabolites
- 1 November 1976
- journal article
- research article
- Published by Springer Nature in Folia Microbiologica
- Vol. 21 (6) , 481-487
- https://doi.org/10.1007/bf02876940
Abstract
The relationship was studied between the energy metabolism of the actinomyceteStreptomyces aureofaciens and the biosynthesis of chlorotetracycline by this organism. The energy charge values in a culture of low-production strain were almost identical with those of a production variant but the total sum of adenylates was about 10 times higher. In the stationary growth phase both strains evinced a drop in energy charge values followed by a rise to the original level. An increase in the concentration of inorganic phosphate in fermentation medium caused a suppression of antibiotic formation in the lowproduction strain and further rise in the total adenylate level. The expression of the energy charge inStreptomyces aureofaciens acquires a complex character owing to the participation, apart from the adenylate system, of high-molecular polyphosphates as energy donors and the probable lack of a regulating mechanism such as the adenylate kinase reaction.Keywords
This publication has 17 references indexed in Scilit:
- Role of ATP-glucokinase and polyphosphate glucokinase inStreptomyces aureofaciensFolia Microbiologica, 1976
- Maintenance of the energy charge in the presence of large decreases in the total adenylate pool of Escherichia coli and concurrent changes in glucose-6-P, fructose-P2 and glycogen synthesisBiochemical and Biophysical Research Communications, 1974
- Quantitative extraction and estimation of intracellular nucleoside triphosphates of Escherichia coliAnalytical Biochemistry, 1972
- Regulation of biosynthesis of secondary metabolites. I. Biosynthesis of chlortetracycline and tricarboxylic acid cycle activityBiotechnology & Bioengineering, 1969
- Use of the liquid scintillation spectrometer for determining adenosine triphosphate by the luciferase enzymeAnalytical Biochemistry, 1969
- Adenosine phosphates and the control of glycolysis and gluconeogenesis in yeastBiochemical Journal, 1969
- Study of adenosine 5′-mono-, di- and triphosphates in plant tissues. IV. Regulation of the level of nucleotides, in vivo, by adenylate kinase: Theoretical and experimental studyBiochimica et Biophysica Acta (BBA) - Bioenergetics, 1968
- Adenosine Triphosphate Conservation in Metabolic RegulationJournal of Biological Chemistry, 1967
- Relationship between the carbohydrate metabolism ofStreptomyces aureofaciens and the biosynthesis of chlortetracyclineFolia Microbiologica, 1964
- The chemical assay of aureomycinJournal of the American Pharmaceutical Association (Scientific ed.), 1949