THE INFLUENCE OF HLA A-B-DR MATCHING ON CYTOMEGALOVIRUS DISEASE AFTER RENAL TRANSPLANTATION

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Abstract
We examined the prevalence of cytomegalovirus infectious episodes, as defined by clinical, virological, and serological criteria (i.e., CMV disease), in 660 kidney graft recipients; 109 patients (16.5%) developed the disease, and 551 did not. No significant statistical link between CMV disease prevalence and a given HLA-A, -B, or -DR allele was observed. However, patients with HLA-DR7 matched grafts were statistically more frequently found (P<0.01) in the group of recipients who developed CMV disease as compared with the group who did not develop CMV disease. Furthermore, among pa

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