Effects ofSkeletonema costatumExtracts on the Central Nervous System
- 1 October 1992
- journal article
- research article
- Published by Georg Thieme Verlag KG in Planta Medica
- Vol. 58 (05) , 398-404
- https://doi.org/10.1055/s-2006-961500
Abstract
We report the effects of aqueous extracts of the microalga Skeletonema costatum Greve (Cleve) (Bacillariophyceae) on spontaneous motor activity, rectal temperature, motor coordination, amphetamineinduced hypermotility, exploratory behaviour, muscle relaxation, catalepsy, conditioned avoidance responses, oxotremorin-induced cholinergic syndrome, and pentylenetetrazole-induced convulsions. The S. costatum extract at dosages of 310 and 620mg/kg works like an antidopaminergic drug with anticholinergic properties, that does not induce catalepsy and with a notable muscle relaxing activity.Keywords
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