A receptor subtype involved in neuropeptide-Y-induced food intake
- 1 July 1996
- journal article
- Published by Springer Nature in Nature
- Vol. 382 (6587) , 168-171
- https://doi.org/10.1038/382168a0
Abstract
Neuropeptide Y (NPY) is a powerful stimulant of food intake and is proposed to activate a hypothalamic 'feeding' receptor distinct from previously cloned Y-type receptors. This receptor was first suggested to explain a feeding response to NPY and related peptides, including NPY2-36, that differed from their activities at the Y1 receptor. Here we report the expression cloning of a novel Y-type receptor from rat hypothalamus, which we name Y5. The complementary DNA encodes a 456-amino-acid protein with less than 35% overall identity to known Y-type receptors. The messenger RNA is found primarily in the central nervous system, including the paraventricular nucleus of the hypothalamus. The extent to which selected peptides can inhibit adenylate cyclase through the Y5 receptor and stimulate food intake in rats correspond well. Our data support the idea that the Y5 receptor is the postulated 'feeding' receptor, and may provide a new method for the study and treatment of obesity and eating disorders.Keywords
This publication has 24 references indexed in Scilit:
- Cloning of a Human Receptor of the NPY Receptor Family with High Affinity for Pancreatic Polypeptide and Peptide YYJournal of Biological Chemistry, 1995
- Cloning and Functional Expression of a Human Y4 Subtype Receptor for Pancreatic Polypeptide, Neuropeptide Y, and Peptide YYJournal of Biological Chemistry, 1995
- Expression Cloning and Pharmacological Characterization of a Human Hippocampal Neuropeptide Y/Peptide YY Y2 Receptor SubtypePublished by Elsevier ,1995
- Cloning and Functional Expression of a cDNA Encoding a Human Type 2 Neuropeptide Y ReceptorJournal of Biological Chemistry, 1995
- Cloning and sequence analysis of a neuropeptide Y/peptide YY receptor Y1 cDNA from Xenopus laevisBiochimica et Biophysica Acta (BBA) - Gene Structure and Expression, 1995
- Neuropeptide Y-Related Peptides and their Receptors--Are the Receptors Potential Therapeutic Drug Targets?Annual Review of Pharmacology and Toxicology, 1993
- The murine NPY‐1 receptor gene Structure and delineation of tissue‐specific expressionFEBS Letters, 1992
- Cloned human neuropeptide Y receptor couples to two different second messenger systems.Proceedings of the National Academy of Sciences, 1992
- Evidence for neuropeptide Y mediation of eating produced by food deprivation and for a variant of the Y1 receptor mediating this peptide's effectPeptides, 1992
- Molecular cloning of a novel G protein‐coupled receptor that may belong to the neuropeptide receptor familyFEBS Letters, 1990