Acid-labile histidine side-chain protection: the N(π)-t-butoxymethyl group
- 1 January 1984
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 5,p. 292-293
- https://doi.org/10.1039/c39840000292
Abstract
N-(α)-Benzyloxycarbonyl-N(π)-t-butoxymethyl -L-histidine (1)and N(α)-fluoren-9-ylmethoxycarbonyl--N(π)-t-butoxymethyl-L-histidine(2)have been prepared and their use for the synthesis of peptides containing histidine residues has been demonstrated in two simple exercises; no difficulties were encountered, the base-and hydrogenolysis-resistant imidazole imidazole protecting group ultimately being removed by mild acidolysis.Keywords
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