Treatment of experimental rabbit infective endocarditis due to a multidrug-resistant Pseudomonas aeruginosa with high-dose ceftazidime alone and combined with amikacin or sulbactam or both
- 1 May 1995
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Antimicrobial Chemotherapy
- Vol. 35 (5) , 697-706
- https://doi.org/10.1093/jac/35.5.697
Abstract
Ceftazidime 800 mg/kg iv was effective when given alone as a continuous infusion to rabbits with aortic valve endocarditis 12 h after infection with a multidrug-resistant strain of P. aeruginosa but only in combination with 100 mg/kg amikacin or 400 mg/kg sulbactam, or both drugs when treatment was begun later.Keywords
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