Grb10 adapter protein as regulator of insulin‐like growth factor receptor signaling

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Abstract
Grb10 is a member of a superfamily of adapter proteins that includes Grb10, 7, 14, and a protein of Caenorhabditis elegans called Mig10. Grb10 proteins are binding partners for several trans‐membrane tyrosine‐kinase receptors, including the insulin‐like growth factor receptor (IGF‐IR) and the insulin receptor (IR). Many recent reports have suggested a very important role of Grb10 in regulating IGF‐IR signaling. In this review, we will focus on the role of Grb10 in IGF‐I‐induced mitogenesis and we will discuss the recent findings that show the involvement of Grb10 in the regulation of ligand‐induced ubiquitination, internalization, and stability of the IGF‐IR. J. Cell. Physiol. 197: 307–311, 2003