Determination of Ethynylestradiol and Norethindrone in Synthetic Intestinal Fluid and in Timed-Release Oral Formulations

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Abstract
High performance liquid chromatographic methods are described for the rapid assay of the antifertility steroids ethynylestradiol and norethindrone in sustained-release oral formulations. A novel method is reported for isolation of these hormones from the synthetic intestinal fluid used for in-vitro release rate studies.