Corticosteroidogenesis by isolated human adrenal cells: Effect of serotonin and serotonin antagonists
- 1 November 1979
- journal article
- Published by Springer Nature in Cellular and Molecular Life Sciences
- Vol. 35 (11) , 1532-1534
- https://doi.org/10.1007/bf01962830
Abstract
The direct effect of serotonin and antiserotonin agents on adrenal steroid biosynthesis was studied in isolated adrenal cells derived from patients with Cushing's syndrome. The results indicate that serotonin increases corticosterone production, while the serotonin antagonists cyproheptadine and methysergide depress adrenal steroid-particularly cortisol and aldosterone-biosynthesis.Keywords
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