Rabbit carotid sinus reflex under pentobarbital, urethan, and chloralose anesthesia
- 1 May 1984
- journal article
- research article
- Published by American Physiological Society in American Journal of Physiology-Heart and Circulatory Physiology
- Vol. 246 (5) , H696-H701
- https://doi.org/10.1152/ajpheart.1984.246.5.h696
Abstract
The effects of different anesthesias on the performance of the arterial baroreflex, the open-loop characteristic of the carotid sinus reflex was analyzed in 24 rabbits under anesthesia with pentobarbital (30 mg/kg), urethan (800 mg/kg), .alpha.-chlorase (80 mg/kg) or a mixture of .alpha.-chloralose (40 mg/kg) and urethan (0.4 g/kg). For each rabbit and anesthesia, mean systemic arterial pressure and heart rate were measured as carotid sinus pressure was changed in 10-mm Hg steps between 40 and 150 mm Hg. This set of measurements was repeated 4 times at 1-h intervals. A logistic function curve was fitted to the carotid sinus pressure-arterial pressure relationship. The parameters of this curve were then analyzed to deliniate the specific effects of the anesthesias on the relationship. The main finding was that the response range and the slope parameters under .alpha.-chloralose anesthesia were significantly smaller than those obtained under the other anesthesias. Propylene glycol, used as the solvent for chloralose, did not affect the reflex control of arterial pressure or heart rate. The reflex under chloralose-urethan anesthesia showed characteristics similar to those under urethan anesthesia. Although .alpha.-chlorase has traditionally been used in the dog to obtain strong reflex responses, it weakens the reflex control of arterial pressure in the rabbit.This publication has 7 references indexed in Scilit:
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