TUMOR INHIBITORS .114. ALOE EMODIN - ANTILEUKEMIC PRINCIPLE ISOLATED FROM RHAMNUS-FRANGULA L

  • 1 January 1976
    • journal article
    • research article
    • Vol. 39  (4) , 223-224
Abstract
A systematic fractionation of an ethanol-water (1:1) extract of the seeds of R. frangula L., guided by assays for tumor inhibitory activity, led to the isolation of aloe emodin. This compound showed significant antileukemic activity against P-388 lymphocytic leukemia in mice. A noteworthy vehicle dependence of the results is reported. In the light of this vehicle dependence, reexamination of other anthraquinone derivatives is recommended.

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