Molecular Cloning of a Feline Leukemia Virus That Induces Fatal Immunodeficiency Disease in Cats
- 19 February 1988
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 239 (4842) , 906-910
- https://doi.org/10.1126/science.2893454
Abstract
A replication-defective variant of feline leukemia virus was molecularly cloned directly from infected tissue and found to induce a rapid and fatal immunodeficiency syndrome in cats. Studies with cloned viruses also showed that subtle mutational changes would convert a minimally pathogenic virus into one that would induce an acute form of immunodeficiency. The data suggest that acutely pathogenic viruses may be selected against by current methods for isolation of the human and simian immunodeficiency viruses.This publication has 21 references indexed in Scilit:
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